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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Myelin protein zero ： ウィキペディア英語版 Myelin protein zero Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the ''MPZ'' gene. P0 is a major structural component of the myelin sheath, and its deficiency due to various mutations in the ''MPZ'' gene is associated with Charcot–Marie–Tooth disease and Dejerine–Sottas disease. ==Function== The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. The P0 glycoprotein, absent in the central nervous system, is a major component of the myelin sheath in peripheral nerves. It comprises a large extracellular N-terminal domain, a single transmembrane region, and a smaller positively charged intracellular domain. It is postulated that P0 is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer, and by interaction between hydrophobic globular `heads' of adjacent extracellular domains.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Myelin protein zero」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.